Every once in a while, my email processing goes completely off the rails and my inbox runs into hundreds (if not thousands) of unprocessed emails. Here's a handy setting in MS Outlook that lets me go super ninja when dealing with an overflowing inbox.
Go to Outlook Options --> Mail --> Others and look for the option After moving or deleting an open item
Setting this option to "Open the next item" forces one to deal with the next item in my inbox as soon as the current item is dealt with.
This tip works very well if you have a bunch of Quick Steps defined that take care of your most common actions.